Typical Symptoms

The symptoms of an Alpha 1 MZ individual are related to a ~50% lower level of Alpha 1 Antitrypsin in the body, and the fact that 50% of the Alpha 1 Antitrypsin gets "stuck" in your liver, which induces liver and digestive issues 

Within the Alpha 1 MZ group we started a correlation study to get a better idea of the most common health issues / symptoms. ( Please note that because lung issues are well known, these were not part of this study) 

This study will be expanded to a large group in the near future.

 

Prevailing health conditions within the small group;

• B12 deficiency, leading to different types of neuropathy

• Vitamin D25 deficiency

• Iron deficiency (some on infusions)

• Intermittent pain in the liver area

• Light color stool, bloating and flatulence

• Only easy to digest food is accepted

• Issues keeping the body warm

• Low glucose levels

• High blood pressure

• Pain in joints (Connective tissues and arthritis)

• Unable to deal with medications like NSAID and/or other medication

• More illness during childhood with lung related issues

• In need of more salt intake was also mentioned (needs further investigation) 

• Reduced immune response, including deficiency of thrombocytes / lymphocytes

• Skin issues like eczema or psoriasis

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Because the study is in a preliminary stage, we can only provide very general information at this stage;

• Lung related issues, like lung emphysema and bronchiectasis

• Liver related issues, Fatty liver, Liver Fibrosis, Cirrhosis 

• Connective tissue related issues, like tendon, tendon sheaths and ligaments

• Immune issues, like autoimmune and immune response issues

• Anti-inflammatory issues  

• Digestive issues causing:

  • B12 / Neurological issues

  • Calcium absorption issues and low Vit D status

  • Iron deficiency  

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Because of the liver/available bile issues, there are digestive / absorption issues  in the small intestine, which causes various vitamin and minerals deficiency issues.